-- an interactive tool for drug combination discovery


© Copyright , Netphar, Faculty of Medicine, University of Helsinki. All Rights Reserved (18.03.2023).

Annotate data

Drug Information


Download Drug Information

Drug Target Information


* Potent targets are defined as the targets displaying binding affinities <= 1,000 nM from the bioactivity databases, or targets recorded in the unary databases. The information comes from MICHA , which integrates the data from 6 databases: DTC , chEMBL , BindingDB , DrugBank , Guide to Pharmacology , DGIdb .

Download Drug Target Information

Cell Line Information


Download Cell Information

Monotherapy

Background grids
Download plot (svg)

Combination

Grids

Synergy Map


Show grids

Synergy Barometer


Selected dose

Tips:

  1. Click on a row in the bar plot to choose a particular dose combination. The barometer will be updated accordingly.
  2. Double click on a panel in the bar plot will sort the entire plot according to that panel.
Download bar plot (svg)
Download barometer (svg)

Synergy-Sensitivity plot (SS plot)


Show labels

Select blocks

Download reports

Static PDF report

Dynamic HTML report

Note: The multi-drug surface plot will not be shown in the static report.

Download data tables

Summary table

Synergy score table

Download R object

R object

1 Prepare Input Data

1.1 Data Format

NB!

1. Synergyfinder Plus (SynergyFinder+) can accept the input files of SynergyFinder3 without any problem.

2. To accommodate the high demand on our servers, we have placed a restriction on the number of drug combinations to a maximum of 12. If you need to process a larger dataset, we recommend using the SynergyFinder R package. Alternatively, feel free to contact us for further assistance.

1.1.1 Table Format

In the Table format, the dose-response data is represented as a long table where each row represent one observation in the dose-response matrix (Fig.1).