-- a FAIR tool for drug combination discovery





Mirror site 1: https://synergyfinder.org/

Mirror site 2: https://tangsoftwarelab.shinyapps.io/synergyfinder/

Standalone download: https://sourceforge.net/projects/synergyfinder/





Drug Information


Download Drug Information

Drug Target Information


* Potent targets are defined as the targets displaying binding affinities <= 1,000 nM from the bioactivity databases, or targets recorded in the unary databases. The information comes from MICHA , which integrates the data from 6 databases: DTC , chEMBL , BindingDB , DrugBank , Guide to Pharmacology , DGIdb .

Download Drug Target Information

Cell Line Information


Download Cell Information

Monotherapy

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Download plot (svg)

Combination

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Synergy Map

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Combination Index Table

Synergy Barometer


Selected dose


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Tips:

  1. Click on a row in the bar plot to choose a particular dose combination. The barometer will be updated accordingly.
  2. Double click on a panel in the bar plot will sort the entire plot according to that panel.


Combination Sensitivity Table

Synergy-Sensitivity plot (SS plot)

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Select blocks

Download reports

Static PDF report

Dynamic HTML report

Note: The multi-drug surface plot will not be shown in the static report.

Download data tables

Summary table

Synergy score table

Download R object

R object

What’s New

16.01.2024-R-3.8.2-dev

Bugs

  • A bug in ZIP function will cause error when the single drug dose response cannot be fitted in high-order drug combinations.

26.09.2023-R-3.8.2-dev

Features

02.09.2023-R-3.8.2-dev

Features

  • Security updates

04.06.2023-R-3.8.2-dev

Bugs

Restrictions

  • We recommend the Bioconductor/R pacakge for large data analysis
  • max number of doses in a matrix: 20
  • max number of rows in an input file: 1250
  • max number of input files in the same session: 10
  • max number of 2-drug combinations in an input file: 12
  • max number of high order drug combinations in an input file: 2

30.04.2023-R-3.8.2

Features

  • Tips are provided for illustrating functionality of the buttons, as well as interpretations of the results
  • Synchronized with the recent updates in the Bioconductor R package version 3.8.2

16.04.2023-R-3.6.3-dev

Features

6.04.2023-R-3.6.3-dev

Restrictions

  • Synergyfinder Plus (SynergyFinder+) is currently under cyber attack. Please be patient if the server is down.
  • Synergyfinder Plus (SynergyFinder+) is compatible with the input files of SynergyFinder3. No format changes are needed.
  • Maximal number of blocks in an input file is 6.
  • Each user has a quota of generated report files. If quota is reached, restart the program.
  • We recommend using the Bioconductor R package for large data analysis.

Features

  • Combination Index is provided as part of synergy result.
  • Missing values before and after imputation can be visualized.

Bugs

  • Synergy barometer is updated when choosing different blocks.
  • Handling of missing values is enabled when calculating statistics.
  • Handling of error catch when monotherapy data is totally missing.

1 Prepare Input Data

1.1 Data Format

1.1.1 Table Format

In the Table format, the dose-response data is represented as a long table where each row represent one observation in the dose-response matrix (Fig.1).