SynergyFinder


an interactive tool for analyzing drug combination dose-response data



example data
Annotate Data



Drug Information


Download Drug Information

Drug Target Information


* Potent targets are defined as the targets displaying binding affinities <= 1,000 nM from the bioactivity databases, or targets recorded in the unary databases. The information comes from MICHA , which integrates the data from 6 databases: DTC , chEMBL , BindingDB , DrugBank , Guide to Pharmacology , DGIdb .

Download Drug Target Information

Cell Line Information


Download Cell Information

Dose Response Curve

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Background grids
Download Plot (SVG)

Dose Response Map (2 Drugs Combination)

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Grids on surface

Synergy Map (2 Drugs Combination)

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Show grids

Selected Data Point


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S-S Plot

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Show labels

Select Blocks to Report

Download Reports for Plots

Static PDF Report

Dynamic HTML Report

Note: The dimention reducted multi-drug surface plot will not be included in 'static report'.

Download Data Tables

Summary Table

Synergy Score Table

Download R Object for SynergyFinder Package

R Object

1 Prepare Input Data

1.1 Data Format

SynergyFinder accepts two formats of input: Table and Matrix.

1.1.1 Table Format

In the Table format, the dose-response data is represented as a long table where each row represent one observation in the dose-response matrix (Fig.1).