SynergyFinder

an interactive tool for analyzing drug combination dose-response data

Correct baseline

1. Choose data format:

example data

Annotate Data

3. Phenotypic Response:

Dose Response Curve

Background grids

Download Plot (SVG)

Color for dots

Color for curve

Dose Response Map (2 Drugs Combination)

Texts size scale

Summary Statistics

Heatmap text label size

Statistics for Replicates

Grids on surface

Plot type

High response value color

Low response value color

Heatmap text label color

Synergy Map (2 Drugs Combination)

Plot type

Summary Statistics

Texts size scale

Synergy effect color

Antagnositic effect color

Grids on surface

Statistics for Replicates

Heatmap text label size

Heatmap text label color

Selected Data Point

Panel title size

Axis text size

Highlited label size

Barometer color

Positive bar color

Negative bar color

Highlighted positive bar color

Highlighted negative bar color

Download Bar Plot (SVG)

Download Barometer (SVG)

S-S Plot

Point color

Point size (mm)

Text label color

Label size (pt)

Show labels

Select Blocks to Report

Download Reports for Plots

Static PDF Report

Dynamic HTML Report

Note: The dimention reducted multi-drug surface plot will not be included in 'static report'.

Download Data Tables

Select output table format

Summary Table

Synergy Score Table

Download R Object for SynergyFinder Package

R Object

1 Prepare Input Data

1.1 Data Format

SynergyFinder accepts two formats of input: Table and Matrix.

1.1.1 Table Format

In the Table format, the dose-response data is represented as a long table where each row represent one observation in the dose-response matrix (Fig.1).