an interactive tool for analyzing drug combination dose-response data


© Copyright , Netphar, Faculty of Medicine, University of Helsinki. All Rights Reserved

Annotate Data

Drug Information


Download Drug Information

Drug Target Information


* Potent targets are defined as the targets displaying binding affinities <= 1,000 nM from the bioactivity databases, or targets recorded in the unary databases. The information comes from MICHA , which integrates the data from 6 databases: DTC , chEMBL , BindingDB , DrugBank , Guide to Pharmacology , DGIdb .

Download Drug Target Information

Cell Line Information


Download Cell Information

Dose Response Curve

Background grids
Download Plot (SVG)

Dose Response Map

Grids on surface

Synergy Map


Show grids

Synergy Barometer and Bar Plot


Selected Data Point

Tips:

  1. Clicking on a specific row in the bar plot will change the highlighted row. Meanwhile the barometer and the table will show the information about the highlighted row.
  2. Double clicking on certain panel in the bar plot will sort the bars according to the values of that panel.
Download Bar Plot (SVG)
Download Barometer (SVG)

S-S Plot


Show labels

Select Blocks to Report

Download Reports for Plots

Static PDF Report

Dynamic HTML Report

Note: The dimention reducted multi-drug surface plot will not be included in 'static report'.

Download Data Tables

Summary Table

Synergy Score Table

Download R Object for SynergyFinder Package

R Object

1 Prepare Input Data

1.1 Data Format

SynergyFinder accepts two formats of input: Table and Matrix.

1.1.1 Table Format

In the Table format, the dose-response data is represented as a long table where each row represent one observation in the dose-response matrix (Fig.1).